Infolongevity » 04 Longevity Genes & Key Molecules

04 Longevity Genes & Key Molecules

0 TERC (Telomerase RNA component)
0 GenBank Overview
0 TERT (Telomerase Reverse Transcriptase)
AMPK | Wikipedia
Follistatin – an overview | ScienceDirect Topics
Follistatin | Wikipedia
FOXO proteins | FoundMyFitness
FOXO Transcription Factors Guide Quick Guide
FOXO1
FOXO3
FOXO3B
FOXO4
FOXO6
FST
Genetics and Human Traits
HGNC – The resource for approved human gene nomenclature
HKDC1 hexokinase domain containing 1 [Homo sapiens (human)]
IGF1
Is longevity determined by genetics? | MedlinePlus Genetics
KL klotho [ Homo sapiens (human) ]
Klotho – Nutrition Consensus
Klotho | What is?
Longevity Science: Is It Based On Genetics? | Spannr
mTOR
mTOR | Biocancer Research Journal
MTOR gene | MedlinePlus Genetics
mTOR inhibitors | Wikipedia
PGC-1α: a key regulator of energy metabolism
PPARGC1A
PRKAA1
PRKAA2
PRKAB1
PRKAB2
PRKAG1
PRKAG2
PRKAG3
Recombinant human Klotho protein (Active) (ab84072) | Abcam
SIRT1
SIRT2
SIRT3
SIRT4
SIRT5
SIRT6
SIRT7
Sirtuins: What are? | Elysium Health
Telomerasa: Qué es y cómo obtenerla (Video)
Telomerase Database
Telomerase Function – Animation
Telomerase Replication in Eukaryotes | End Replication
Telomerase reverse transcriptase (TERT) | Wikipedia
Telomerase: What is? | AgeX Therapeutics (Video)
Telomeres and Telomerase – Infoaging guide (AFAR)
VGNC – Vertebrate Gene Nomenclature Committee
What is Nicotinamide Mononucleotide? A Summary of NMN
2024-12-03 Building a “Google Maps” for Biology: Human Cell Atlas Revolutionizes Medicine
2024-11-26 Longevity biotech spawns klotho-focused subsidiary
2024-11-14 The Role of Serum α-Klotho in Preventing Hearing Impairment among Middle-aged and Older Adults
2024-09-23 OSER1: Un nuevo gen clave para la longevidad
2024-07-08 Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways
2024-06-11 Knockout of the longevity gene Klotho perturbs aging and Alzheimer’s…
2024-06-02 mTOR: Its Critical Role in Metabolic Diseases, Cancer, and the Aging Process
2024-05-10 Klotho is highly expressed in the chief sites of regulated potassium secretion
2024-03-21 An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway
2024-03-03 Beyond Limitless: Unveiling the Real NZT-48, Klotho Gene Therapy
2024-02-15 Influence of AMPK on the Functioning of the Circadian Clock and…Age-Related Metabolic Disorders
2024-01-30 Klotho: Gene Therapy for Chronic Kidney Disease
2024-01-29 Cómo aumentar la proteína klotho que combate el envejecimiento del cerebro y nos hace jóvenes
2024-01-18 Of Yeast and Men: Longevity and Sirtuins
2024-01-03 HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence
2024-01-01 HKDC1 protein found crucial to maintaining two mitochondria subcellular structures
2023-11-27 SIRT2 transgenic over‐expression does not impact lifespan in mice
2023-11-25 How Is SIRT6 Linked to Life Extension #shorts
2023-11-15 Heteroskedasticity as a Signature of Association for Age-Related Genes
2023-11-15 Life Extension Genes – do you have them? [6 Studies]
2023-11-13 Foxp3 protein governs regulatory T cell genome structure
2023-11-12 Turn On Mitochondrial SIRT3 To Get Extra Longevity Benefits | Dr David Sinclair Interview Clips
2023-11-07 New Insights on Foxp3: Unraveling the Complexity of Regulatory T Cell Function
2023-11-03 L-shaped association of serum α-Klotho and frailty among the middle-aged and older adults
2023-10-24 Activation of mTOR signaling in adult lung microvascular progenitor cells accelerates lung aging
2023-10-23 25 Longevity Genes You Should Know
2023-10-17 The Importance of α-Klotho in Depression and Cognitive Impairment…
2023-10-10 SIRT2 Works Against Cardiac Aging in Mice and Monkeys
2023-10-02 Multifaceted role of mTOR signaling pathway in human health and disease
2023-10-02 SIRT2 counteracts primate cardiac aging
2023-10-02 SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B
2023-09-28 SIRT6 The Science Behind The Longevity Gene | Professor Vera Gorbunova
2023-09-26 Follistatin, Gene Therapy, Muscle Mass, and Longevity
2023-09-25 Integrative GWAS and……suggests novel genes associated with age-related multimorbidity
2023-09-21 FOXO: A Key to Slowing Aging & Preventing Diseases
2023-09-17 Klotho and The Thread of Life
2023-09-08 Longevity to a sirtuin extent
2023-08-21 Suppression of FOXO1 attenuates inflamm‐aging and improves liver function during aging (in mice)
2023-08-17 Klotho and telomere length may be associated through a coordinated downregulation of longevity factors
2023-08-16 AAV‐Mediated nuclear localized PGC1α4 delivery in muscle ameliorates sarcopenia
2023-08-16 Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
2023-08-15 Evolutionary analysis of the mTOR pathway provide insights into lifespan extension across mammals
2023-08-14 Associations between klotho and telomere biology in high stress caregivers
2023-08-06 New Insights Into The Anti-Aging Properties Of Klotho
2023-07-09 NAD metabolism: Role in senescence regulation and aging
2023-07-05 Proteína klotho: cómo aumentarla y mantenerla para combatir el envejecimiento
2023-07-04 Anti-ageing protein injection boosts monkeys’ memories
2023-07-03 Hormone injection may stem age-related memory decline
2023-07-03 Longevity factor klotho enhances cognition in aged nonhuman primates
2023-06-24 mTOR in programmed cell death and its therapeutic implications
2023-06-23 Gene expressions associated with longer lifespan and aging exhibit similarity in mammals
2023-06-17 TFEB is a central regulator of the aging process and age-related diseases
2023-06-12 Sirtuins May Help Against Inflammatory Spinal Degeneration
2023-05-21 Resveratrol Increases SIRT1 Activity 106% In Human Trial
2023-05-17 Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity
2023-05-16 Does SIRT6 hold the key to human longevity?
2023-05-10 A draft human pangenome reference
2023-05-09 Klotho Protein: Gene Therapy to Slow Aging and Improve the Brain
2023-05-04 Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish
2023-05-04 Targeting the biology of aging with mTOR inhibitors
2023-05-04 The mTOR signaling pathway in cardiac aging
2023-04-19 Speaking of Illusions: Sirtuins and Longevity
2023-04-18 Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines
2023-04-17 SIRT4 in ageing
2023-04-11 Why NAD is So Crucial To Our Life? 6 Major Studied Benefits
2023-04-09 Parishin alleviates vascular ageing in mice by upregulation of Klotho
2023-03-15 Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila
2023-03-14 Cambrian Bio reveals new company to focus on AMPK activation
2023-03-03 How NAD+ Relates to Smell Loss with Age
2023-03-01 ‘Longevity Protein’ Key to Knee Cartilage Health?
2023-02-25 NAD+ & Heart Failure – Relationship Identified
2023-02-20 Klotho: Hope For Increased Longevity And Reduced Neurodegenerative Disease (Part 1)
2023-02-13 A Relationship Between NAD+ and Gradual Heart Failure
2023-02-13 NMN alters body composition and ameliorates metabolic disorders induced by a high‐fat diet
2023-02-08 Pgc-1α is an exercise-responsive regulator of myosteatosis in older individuals
2023-02-08 What Are Sirtuins And How Do They Relate To Aging And Disease?
2023-02-01 A meta-analysis of RNA-Seq studies to identify novel genes that regulate aging
2023-01-22 NMN Activates SIRT3 To Rescue Senescent Stem Cells
2023-01-18 New AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously in C. ellegans
2023-01-18 SIRT6 is a key regulator of mitochondrial function in the brain
2023-01-16 Follistatin’s Role In Liver Defense And Cancer
2023-01-16 Targeting AMPK Pathway To Extend LIFESPAN
2023-01-16 Turn on Your Longevity Genes – Secret Reason Why Centenarians Live So Long
2023-01-11 Relationship between the development of arthritis in the elderly and a deficiency of the Klotho protein
2023-01-10 Age-related matrix stiffening epigenetically regulates α-Klotho expression…
2022-12-31 Why Is Longevity Still a Scientific Mystery? Sirtuins – Past, Present and Future
2022-12-29 The sirtuin family in health and disease
2022-12-23 On the Aging of the Kidneys
2022-12-07 Klotho Protein Decreases MMP-Mediated Degradation of Contractile Proteins during Ischaemia
2022-11-27 Klotho protein levels protect against cognitive decline in Alzheimer patients
2022-11-27 mTOR Inhibitors Human Trials : Reversal Of Aged Immune System
2022-11-27 mTOR Inhibitors Human Trials: Reversal Of Aged Immune System
2022-11-14 Reduced serum Klotho levels are associated with MCI
2022-11-11 The role of mTORC1 in the regulation of skeletal muscle mass
2022-11-09 Dr. Haim Cohen – The Protective Role of SIRT6 on Aging and Longevity
2022-11-02 Klotho Reduces Arterial Calcification Through Autophagy
2022-10-26 Klotho Ameliorates Vascular Calcification via Promoting Autophagy
2022-10-13 Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5
2022-09-22 Sirtuins are not conserved longevity genes | Oxford Academic
2022-09-13 A Role for PGC-1a in the Control of Abnormal Mitochondrial Dynamics in Alzheimer´s Disease
2022-09-05 “Longevity Molecules” Preserve Hair & Hearing in Mice
2022-09-04 Role of Sirtuins in Diabetes and Age-Related Processes
2022-08-14 Is It Really Good to Have the Sirtuin Genes Activated Full Time?
2022-08-12 Arise Sir-Tuin: Why sirtuins are the knights battling ageing
2022-08-12 FOXO3, a Resilience Gene: Impact on Lifespan, Healthspan, and Deathspan
2022-08-06 mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
2022-08-06 NAD+ to assess health in aging humans
2022-08-03 Longevity sirtuin (SIRT6) clinical trial teases promising results
2022-07-30 Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review
2022-07-29 mTOR’s Role In Metabolism | Dr Ted Naiman Ep 3
2022-07-25 NAD+ Helps Natural Killer Cells to Fight Cancer
2022-07-25 Researchers discover gene that promotes muscle strength during exercise
2022-07-23 Gene Regulation Might Be the Key to a Longer Lifespan
2022-07-21 What Health Benefits Can We Get When Sirtuins Have More NAD? | David Sinclair’s Clip
2022-07-12 Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations
2022-07-11 The genetics of successful ageing: unlocking longevity genes in humans
2022-06-29 Increasing Muscle Hypertrophy with a Natural Product Designed to Inhibit SIRT1
2022-06-29 Stop Accelerating Aging – The 2 Main Roles of Sirtuns | David Sinclair Clip
2022-06-20 220620 These genes could be the key to longer lifespans
2022-06-05 What Are Sirtuins and What Do They Do?
2022-05-21 SIRT6: What We Can Learn From Centenarians
2022-05-11 How many sirtuin genes are out there?
2022-05-10 Involvement of the SIRT1/PGC-1α Signaling Pathway in Noise-Induced Hidden Hearing Loss
2022-05-10 SIRT3 deficiency decreases oxidative-metabolism capacity but increases lifespan under caloric restriction
2022-05-08 Sirtuin 6 : Summary Of Key Points of Professor Cohen Interview
2022-05-01 SIRT6 – The Most Potent Sirtuin | David Sinclair Clip
2022-04-26 Targeting NAD+: is it a common strategy to delay heart aging?
2022-04-15 AMPK and mTOR: How Often Can We Make the Switch?
2022-04-15 Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity
2022-04-11 Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity
2022-03-29 Genflow collaborates with Aging Research Centre to drive sirtuin research
2022-03-24 SIRT1, SIRT3 Levels May Be Useful Biomarkers of Disease Severity
2022-03-14 Association between serum uric acid and α-klotho protein levels in the middle-aged population
2022-03-03 Human lifespan is linked to truncating variants in single genes
2022-03-02 p53: Guardian of the Genome
2022-02-17 Healthy aging and muscle function are positively associated with NAD+ abundance in humans
2022-02-04 A dead cert for longevity: why Sirt6 is the enzyme making headlines
2022-01-28 Genes and Longevity of Lifespan
2021-12-23 Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases
2021-12-23 Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases
2021-12-20 Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy
2021-12-18 Association between the anti-aging protein klotho with sleep
2021-11-25 Get mTOR Right For Longevity | Dr David Sinclair Interview Clip
2021-11-25 Sirtuins at the Service of Healthy Longevity
2021-11-22 Klotho: The protein that could extend your healthspan and lifespan
2021-11-06 Activation of Akt–mTORC1 signalling reverts cancer‐dependent muscle wasting
2021-11-02 Patients with Earlobe Crease May Associate with Lower Concentration of the Hormone Klotho
2021-10-20 Lack of Klotho Associated With All-Cause Mortality
2021-10-19 Klotho as Potential Autophagy Regulator and Therapeutic Target
2021-10-06 mTOR-Driven Aging and Rapamycin with Mikhail Blagosklonny and Dennis Mangan
2021-09-25 Sirtuin 1, Sirtuin 3 & Sirtuin 6: Which One is the Coolest?
2021-09-21 Dissecting the biology of mTORC1 beyond rapamycin
2021-09-08 MTOR Inhibition Leads to 30% Life Extension in Progeric Mice
2021-09-02 Insulin/IGF-1 signaling promotes immunosuppression: impact on the aging process and age-related diseases
2021-08-27 Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
2021-08-26 What Is NAD+? Longevity Boosts of Nicotinamide Adenine Dinucleotide & NMN
2021-08-23 Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin
2021-08-07 Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity
2021-07-24 Sirtuins Anti Aging Revisited. What they are. Why you should care. How you can benefit.
2021-07-17 Sirtuin 6: linking longevity with genome and epigenome stability
2021-07-16 Sirtuin3 ameliorates lung senescence and improves type II alveolar epithelial cell function
2021-06-24 Scientists may need to rethink which genes control aging, study suggests
2021-06-24 Study suggests scientists may need to rethink which genes control aging
2021-06-11 Researchers Substantially Extend Mouse Lifespan by Activating NAD+-Dependent and Energy Balancing Enzyme
2021-06-06 SIRT6 Positively Affects The Hallmarks Of Aging And Extends Lifespan
2021-06-02 SIRT6 Overexpression Extends Lifespan in Mice
2021-05-28 Restoration of energy homeostasis by SIRT6 extends healthy lifespan in mice
2021-05-28 The Role of PGC1α in Alzheimer’s Disease and Therapeutic Interventions
2021-04-30 What is NAD+? | Dr Matt & Dr Mike
2021-04-20 The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function
2021-04-19 Network analysis in aged C. elegans reveals candidate regulatory genes of ageing
2021-04-15 The Key Role of NAD+ in Anti-Tumor Immune Response: An Update
2021-03-29 SIRT6 in Senescence and Aging-Related Cardiovascular Diseases
2021-03-18 Understanding the Role of Sirtuin 2 on Aging: Consequences of SIRT2.3 Overexpression in Senescence
2021-03-05 Reduced insulin/IGF1 signaling prevents immune aging
2021-03-03 Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk
2021-02-18 How to Increase SIRTUINS for Longevity
2021-02-18 Sirtuins and NAD Supplements for Longevity
2021-02-09 Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis
2021-01-30 How a Klotho Variant Aids Klotho Production and Protects the Brain
2021-01-25 G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
2020-12-09 Genes for Regulating Stem Cell Aging Identified
2020-12-01 Gene Responsible for Cellular Aging in Human Cells Identified
2020-11-16 Chronic inflammation causes a reduction in NAD+
2020-11-11 Longevity Genes: APOE
2020-10-26 Study finds PTSD interacts with klotho gene, may cause premature aging in the brain
2020-10-26 SynergyAge, a curated database for interactions of longevity-associated genes
2020-09-29 Sirtuin 6: A potential therapeutic target for cardiovascular diseases
2020-09-29 The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators
2020-09-24 Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin
2020-09-22 Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1
2020-09-21 Klotho overexpression improves amyloid‐β clearance and cognition in mouse model of Alzheimer
2020-09-17 Factors that increase Klotho (protein) + gene associations
2020-09-17 Telomerase Gene Therapy with Liz Parrish and Dr. Jason Williams
2020-09-15 How mTOR Impacts Aging
2020-09-09 The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
2020-09-07 Re-activating Youth Boosting Genes to Reverse Human Aging By 2030
2020-09-01 Telomerase RNA processing: implications for human health and disease
2020-08-27 Klotho, Aging, and the Failing Kidney
2020-08-25 Towards a Telomerase Gene Therapy for Pulmonary Fibrosis
2020-08-20 AAV delivery of glutathione reductase gene attenuates klotho deficiency-induced kidney damage
2020-08-18 IGF-1 Reverses Mitochondrial Decline in Smooth Muscular Cells
2020-08-17 Inhibition of mTOR decreases insoluble protein burden by reducing translation in C. elegans
2020-08-15 Follistatin: Muscle Growth with a Myostatin Inhibitor?
2020-08-14 mTOR and the Science of Aging and Chronic Disease
2020-08-14 The Benefits of Increased PGC-1alpha Expression
2020-08-12 AMPK regulation of Raptor and TSC2 mediate metformin effects on anabolism and inflammation
2020-07-31 Klotho Gene Therapy with Dr. Jason Williams and Liz Parrish
2020-07-30 Sirtuins and their biological relevance in aging and age-related diseases
2020-07-28 FOXO3a acts to suppress DNA double‐strand break‐induced mutations
2020-07-19 The secrets of telomerase: Retrospective analysis and future prospects
2020-07-17 IGF-1 – The Definitive Guide | Biology Dictionary
2020-07-12 Hematopoietic Stem and Progenitor Cell Aging is Initiated at Middle Age Through Decline in Local IGF1
2020-07-06 Peter Attia: Rapamycin, mTOR inhibition, and the biology of aging
2020-06-30 Cómo la proteína AMPK puede pasar de suprimir a promover el crecimiento tumoral
2020-06-23 Klotho and the Treatment of Human Malignancies
2020-06-22 Dr. Carmela Abraham – Klotho: The Key to Longevity
2020-06-02 Effects of GH/IGF on the Aging Mitochondria
2020-05-18 Follistatin gene therapy doubles muscle mass in mice
2020-05-17 New Gene Therapy Promises You Will Get Ripped Without Stepping in a Gym
2020-05-12 Terapia génica con folistatina para adelgazar y aumentar músculo
2020-05-11 Gene Therapy in Mice Builds Muscle, Staves off Obesity, and Reduces Osteoarthritis Pain
2020-05-08 Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in mice
2020-05-06 Functional effects of muscle PGC-1alpha in aged animals
2020-05-04 Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors
2020-05-01 Ageing and longevity genes in cardiovascular diseases
2020-04-27 Restoring Telomerase Activity in Telomere Biology Diseases
2020-04-23 SynergyAge: a curated database for synergistic and antagonistic interactions of longevity genes
2020-04-22 FOXO1 deficiency impairs proteostasis in aged T cells
2020-04-21 Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells
2020-04-13 Association of Klotho-VS heterozygosity with risk of Alzheimer disease
2020-04-03 Follistatin: A Myostatin Inhibitor for Muscle Health with Liz Parrish and Integrated Health Systems
2020-03-23 The continuing evolution of insulin-like growth factor signaling
2020-03-14 Sirtuins: Potential Therapeutic Targets for Regulating Acute Inflammatory Response?
2020-03-13 The flip side of sirtuins: the emerging roles of protein acetyltransferases in aging
2020-03-11 A new protein curbs the hypertrophic effect of myostatin inhibition in mice
2020-03-03 The mTOR pathway is necessary for survival of mice with short telomeres
2020-02-28 Spatial regulation of mTORC1 signalling: Beyond the Rag GTPases
2020-02-25 Natural Ways to Boost PGC-1α
2020-02-17 Programmable base editing of mutated TERT promoter inhibits brain tumour growth
2020-02-11 NAD+ Repletion Rescues Female Fertility during Reproductive Aging
2020-01-24 FOXO1 and FOXO3 have unique functions in meniscus development and homeostasis during aging
2020-01-22 Combination therapy of α-KLOTHO and TGFβR2 improves osteoarthritis
2020-01-17 Peter Attia: An overview of mTOR and IGF-1
2020-01-14 mTOR at the nexus of nutrition, growth, ageing and disease
2020-01-09 DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of longevity promoting genes
2020-01-06 Peter Attia interviews David Sinclair on slowing aging, sirtuins, NAD, and the epigenetics of aging
2020-01-02 DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling
2019-12-03 Identification of genes associated with longevity in Drosophila melanogaster, a computational approach
2019-11-18 The Strategy of mTORC1 Inhibition Fails a Phase III Trial
2019-11-12 Insulin-Like Growth Factor-1 Is Neuroprotective in Aged Rats With Ischemic Stroke
2019-10-28 Evaluation of Safety and Tolerability of Libella Gene Therapy for Alzheimer’s Disease: AAV- hTERT
2019-10-20 Proposed Tandem Effect of Physical Activity and Sirtuin 1 and 3 Activation in Regulating Glucose Homeostasis
2019-10-04 Qué es mTOR y por qué te importa
2019-09-13 Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity
2019-09-03 Transient induction of telomerase expression mediates senescence and reduces tumorigenesis
2019-08-23 Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline
2019-08-23 Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives
2019-08-21 Sirtuins in Aging
2019-08-14 A meta-analysis of genome-wide association studies identifies multiple longevity genes
2019-08-13 Klotho: la hormona que podría frenar el envejecimiento y potenciar el cerebro
2019-08-11 Mechanisms involved in follistatin‐induced hypertrophy and increased insulin action in skeletal muscle
2019-08-01 Hypothalamic mTORC2 is essential for metabolic health and longevity in Mice
2019-07-25 Downregulation mTOR Signaling Increases Stem Cell Population Telomere Length in Planarians
2019-07-16 Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins
2019-07-16 PGC‐1α, a potential therapeutic target against kidney aging
2019-07-12 Liz Parrish interviewed by Brent Nally about her telomerase & myostatin inhibitor gene therapies
2019-07-03 PGC‐1α integrates a metabolism and growth network linked to caloric restriction
2019-07-02 mTOR as a central regulator of lifespan and aging
2019-06-29 Anti-Aging Protein Shown To Be Neuroprotective
2019-06-28 Anti-aging protein hormone Klotho shown to be neuroprotective in ALS model
2019-06-28 Dietary restriction induces posttranscriptional regulation of longevity genes
2019-06-26 Muscle Mass and Myostatin Inhibition with Liz Parrish
2019-06-21 Telomerase Gene Therapy with Liz Parrish
2019-06-13 FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs
2019-06-10 The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts
2019-06-04 Proteína Klotho para frenar el envejecimiento y potenciar el cerebro
2019-06-04 Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease
2019-06-03 What Is Klotho and will it really “induce age-reversal”?
2019-05-15 PES1 is a critical component of telomerase assembly and regulates cellular senescence
2019-05-07 Age-Dependent Changes in Transcription Factor FOXO Targeting in Female Drosophila
2019-04-18 All About mTOR & Natural mTOR Inhibitors
2019-04-16 KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD
2019-04-11 FOXO3 directly regulates an autophagy network to regulate proteostasis in adult neural stem cells
2019-04-02 Existe una droga capaz de mejorar el alzhéimer: ¿deberíamos tomarla?
2019-04-02 Is Klotho the key to treating Alzheimer’s and other diseases of aging?
2019-03-20 Gene variant associated with cellular aging
2019-03-15 Alzheimer’s and Longevity Genes: Are They Connected?
2019-03-13 Leonhardt’s Launchpads Announces Filing of Patent for Bioelectric Stimulation Controlled Klotho Expression
2019-03-11 Longevity gene klotho (KL) is associated with age-related phenotypes
2019-03-08 Insulin and IGF-1 in human aging and longevity
2019-03-07 Klotho: An Elephant in Aging Research
2019-02-22 Next generation strategies for geroprotection via mTORC1 inhibition
2019-02-15 Cell Senescence, Telomerase, and Senolytic Therapy
2019-02-13 Telomeres and telomerase: three decades of progress
2019-02-08 Integrator is a key component of human telomerase RNA biogenesis
2019-02-03 Using FOXO4-DRI to eradicate senescent cells
2019-02-01 ROLE of IGF-1 System in the Modulation of Longevity
2019-01-31 Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells
2019-01-31 Sirtuin signaling in cellular senescence and aging
2019-01-15 Health effects of metabolic ‘magic bullet’ enzyme AMPK
2019-01-06 A Deeper Look At Human Longevity Genes
2019-01-02 Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD
2018-12-17 ¿Qué es la telomerasa y como obtenerla? (María Blasco, Elizabeth Blackburn)
2018-12-07 Pathogenic TERT promoter variants in telomere diseases
2018-11-28 Telomere length and telomerase activity in T cells are biomarkers of high‐performing centenarians
2018-11-21 Longevity Protein (Klotho) Rejuvenates Muscle Healing in Old Mice
2018-11-19 Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction
2018-11-15 Too much mTOR is linked to Diabetes and aging
2018-11-12 Scientists uncover new gatekeeper function of anti-aging molecule
2018-11-07 David Sinclair: Longevity Genes
2018-10-23 DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote longevity
2018-10-22 The role of klotho in chronic kidney disease
2018-09-06 The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling
2018-09-01 Mastering the mTOR Pathway for Longevity and Performance
2018-08-31 Klotho and Postmenopausal Hormone Replacement Therapy in Women with Chronic Kidney Disease
2018-08-24 Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
2018-08-20 Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals
2018-08-17 CT: Evaluating Sirtuin Supplements To Benefit Elderly Trauma Patients (BES2T BET)
2018-08-10 Klotho, the Key to Healthy Brain Aging?
2018-08-08 mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases
2018-07-30 Klotho protein in neurodegenerative disorders
2018-07-27 Hormona para potenciar la quimioterapia frente al cáncer de pulmón
2018-07-11 Back pain and FOXO, an anti-aging equation
2018-07-01 40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain
2018-06-19 Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
2018-06-06 3-D structure of telomerase’s catalytic core
2018-06-03 Immortal cell lines & telomerase
2018-05-30 Klotho is upregulated in human cardiomyopathy independently of circulating Klotho levels
2018-05-25 Klotho: marker of chronic kidney disease progression and cardiovascular complications?
2018-05-25 Scientists unveil structure of the ‘immortality’ enzyme telomerase
2018-05-24 Are scientists closer to unraveling the code of aging?
2018-05-16 The Emerging Roles for Telomerase in the Central Nervous System
2018-05-10 Cryo-EM structure of substrate-bound human telomerase holoenzyme
2018-04-25 End of ageing and cancer? Scientists unveil structure of the ‘immortality’ enzyme telomerase
2018-04-25 Long-sought structure of telomerase paves way for drugs for aging, cancer
2018-04-10 How to Increase Klotho (Protein) + Gene Associations
2018-04-01 Telomerase May Paradoxically Accelerate Aging of the DNA Methylome
2018-03-30 Role of Forkhead Box O (FOXO) transcription factor in aging and diseases
2018-03-29 Anti-aging protein alpha Klotho’s molecular structure revealed
2018-02-27 Hidden secret of immortality enzyme telomerase: Can we stay young forever, or even recapture lost youth?
2018-02-15 mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review
2018-02-14 FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis
2018-02-13 FOXO3 and Exceptional Longevity: Insights From Hydra to Humans
2018-02-12 A single nucleotide incorporation step limits human telomerase repeat addition activity
2018-02-10 Overexpression of PGC‐1α in aging muscle enhances a subset of young‐like molecular patterns
2018-02-05 Liz Parrish discusses 2yr follow-up from telomerase gene therapy
2018-02-05 Se descubre la estructura de la hormona antienvejecimiento
2018-02-02 Genetic Cartography of Longevity in Humans and Mice: Current Landscape and Horizons
2018-01-30 Could a protein called klotho block dementia and aging?
2018-01-26 GWAS of epigenetic aging rates in blood reveals a critical role for TERT
2018-01-19 Role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance
2018-01-17 Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
2017-12-22 Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease
2017-12-12 Identification and characterization of two functional variants in the human longevity gene FOXO3
2017-12-05 Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
2017-11-15 Amish gene can make them live 10 years longer and avoid diabetes
2017-11-07 Human Ageing Genomic Resources: new and updated databases
2017-10-31 Secreted [alpha]Klotho isoform protects against age-dependent memory deficits
2017-10-25 Twenty-five years of mTOR: Uncovering the link from nutrients to growth
2017-10-17 mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass
2017-09-29 FOXO Genes and Human Longevity
2017-09-06 Michael Hall: The Story of TOR (Target of Rapamycin)
2017-08-09 La hormona de la longevidad klotho estimula la memoria y protege del envejecimiento cerebral
2017-07-27 Bayesian association scan reveals loci associated with human lifespan and linked biomarkers
2017-07-18 Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies
2017-07-15 An Example of Senolytic Self-Experimentation with FOXO4-DRI
2017-07-15 Potential application of klotho in human chronic kidney disease
2017-07-11 Leonard Guarente: Sirtuins and NAD
2017-07-03 Increased Expression of Follistatin in Breast Cancer Clinically Correlates with Better Survival
2017-06-19 Anti aging FOXO4-DRI explained
2017-03-24 Una terapia experimental revierte el envejecimiento en ratones (FOXO4-DRI)
2017-03-03 Sirtuins, a promising target in slowing down the ageing process
2017-02-18 Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species
2017-02-05 AMPK Signaling Pathway: Regulation and Downstream Effects
2017-02-02 Acute upregulation of PGC-1α mRNA correlates with training-induced increases in SDH activity
2017-01-20 Klotho, la proteína que puede ayudar a preservar la función renal
2017-01-09 Leonard Hayflick Discussing Aging Research, Telomeres, and Telomerase (1 of 4)
2017-01-09 Leonard Hayflick Discussing Aging Research, Telomeres, and Telomerase (2 of 4)
2017-01-09 Leonard Hayflick Discussing Aging Research, Telomeres, and Telomerase (3 of 4)
2017-01-09 Leonard Hayflick Discussing Aging Research, Telomeres, and Telomerase (4 of 4)
2016-11-30 Cellular Aging: Telomeres & Telomerase, Sirtuins
2016-11-08 A full explanation about the Telomerase and the end replication problem
2016-10-24 Roy Walford lecture: NAD, Sirtuins and Aging – Leonard P. Guarente, PhD
2016-10-11 Metformin Activates AMPK through the Lysosomal Pathway
2016-09-15 The Secret to Longevity is in Our Genes
2016-08-30 Klotho: a humeral mediator in CSF and plasma that influences longevity
2016-08-22 Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly
2016-07-15 Regulation and function of AMPK in physiology and diseases
2016-06-20 Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
2016-05-30 Reviewing what is known of FGF23 and Klotho signaling in aging
2016-04-01 AMPK activators: mechanisms of action and physiological activities
2016-03-09 Mammalian target of rapamycin (mTOR) inhibitors in solid tumours
2016-03-05 El secreto de la eterna juventud: LA TELOMERASA. Entrevista a María Blasco
2016-01-30 Nutrition and lifestyle in healthy aging: the telomerase challenge
2015-12-31 AMPK activation can delay aging
2015-12-29 Results from a Myostatin Antibody Trial to Boost Muscle Mass and Strength in the Old
2015-12-11 Evaluation of follistatin as a therapeutic in models of skeletal muscle
2015-12-08 Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
2015-10-08 Telomerase: The Instrument of Cell Immortality
2015-06-09 El secreto de la inmortalidad: La telomerasa
2015-04-08 An Introduction to IGF-1 in Aging
2015-04-01 PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
2015-03-28 FOXO3: A Major Gene for Human Longevity
2015-01-25 Tumor Suppressor Activity of Klotho in Breast Cancer Is Revealed by Structure-Function Analysis
2014-12-24 mTOR inhibition improves immune function in the elderly
2014-11-05 In vivo pancreatic β-cell-specific expression of antiaging gene Kloth
2014-10-30 Why genes extending lifespan in model organisms have not been consistently associated with human longevity
2014-09-09 Activating gene AMPK in key organ systems slows aging process throughout the body
2014-07-18 The NAD+/sirtuin pathway modulates longevity
2014-06-12 The controversial world of sirtuins
2014-05-22 Life Extension Factor Klotho Enhances Cognition
2014-05-11 Gene that increases intelligence found by scientists sparking new hope for dementia sufferers
2014-05-08 Anti-aging factor offers brain boost, too
2014-05-08 The 3% solution | Genes and intelligence
2014-04-13 Leonard Guarente: NAD and sirtuin activators – Part 4
2013-10-05 Bill Andrews: Telomere Scientist and Therapeutic Telomerase Pioneer
2013-08-12 Dissociation of Increases in PGC-1α and Its Regulators from Exercise Intensity
2013-06-09 The GH/IGF-1 axis in ageing and longevity
2013-05-15 Genes que modifican la extensión de la vida: longevidad y envejecimiento prematuro
2013-04-10 Role of PGC-1α in muscle function and aging
2013-03-01 Rapalogs and mTOR inhibitors as anti-aging therapeutics
2013-01-22 Telomerase reverse transcriptase synergizes with calorie restriction to increase health span
2013-01-17 mTOR is a key modulator of ageing and age-related disease
2013-01-11 mTOR in aging, metabolism, and cancer
2012-11-30 The Genetics of Extreme Longevity: Lessons from the New England Centenarian Study
2012-11-13 Solving the mystery of aging: Longevity gene makes Hydra immortal and humans grow older
2012-10-18 Potential of telomerase activation in extending health span and longevity
2012-08-23 The controversial world of sirtuins
2012-06-25 Sirtuin activators and inhibitors
2012-06-05 Klotho as a potential biomarker and therapy for acute kidney injury
2012-05-15 Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
2012-03-28 Genes Against Aging
2012-02-22 The sirtuin SIRT6 regulates lifespan in male mice
2012-01-01 The role of mTOR signaling in Alzheimer disease
2011-12-05 Telomerasa y envejecimiento: La Fuente de la Juventud
2011-09-29 Mammalian target of rapamycin (mTOR): a signaling kinase for every aspect of cellular life
2011-09-21 Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
2011-09-21 Is The Longevity Gene Sirtuin One Big Research Error?
2011-09-21 Longevity genes (sirtuins) challenged
2011-09-21 Sirtuins are Increasingly Looking Like a Dead End
2011-08-12 Regulation of Foxo-Dependent Transcription by Post-Translational Modifications
2011-06-01 Klotho and the aging process
2011-05-05 Mitochondria and PGC-1α in Aging and Age-Associated Diseases
2011-03-15 Sirtuins at a glance | Journal of Cell Science
2010-11-28 Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
2010-11-28 Telomerase reverses ageing process in mice studies
2010-10-29 Nir Barzilai: Longevity genes
2010-08-03 The role of telomeres and telomerase in stem cell aging
2010-07-19 Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
2010-06-15 Importancia de los telómeros y la telomerasa en cáncer, envejecimiento y medicina regenerativa
2010-05-15 Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
2010-01-26 Relevant use of Klotho in FGF19 subfamily signaling system in vivo
2009-10-05 El Nobel de Medicina premia a los padres de la telomerasa, la enzima de la juventud celular
2009-05-15 Immunoregulatory Functions of mTOR Inhibition
2009-04-14 PGC-1α in aging and anti-aging interventions
2009-02-10 Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease
2008-12-20 mTOR-what does it do?
2008-11-26 Mice share yeast’s ageing system
2008-11-21 The Klotho gene family as a regulator of endocrine fibroblast growth factors
2008-11-14 Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
2008-07-27 Myostatin inhibition by follistatin-derived peptide ameliorates pathophysiology of muscular dystrophy model mice
2008-01-28 50% Maximum Life Extension in Mice Via p53 and Telomerase
2008-01-17 Telomerase does not counteract telomere shortening but protects mitochondrial function
2007-10-22 Telomerase reverses epidermal hair follicle stem cell defects
2007-08-29 Quadrupling Muscle Mass in Mice by Targeting TGF-ß Signaling Pathways
2007-06-01 Stressing the role of FoxO proteins in lifespan and disease | Nature Reviews Molecular Cell Biology
2006-12-30 PGC-1alpha: a key regulator of energy metabolism
2006-12-19 Telomerase induction in T cells: a cure for aging and disease?
2006-12-01 Unlocking the Secrets of Longevity Genes
2006-10-01 The mTOR Pathway in the Control of Protein Synthesis
2006-07-15 Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism
2006-02-10 mTOR Signaling in Growth and Metabolism
2005-08-25 Suppression of Aging in Mice by the Hormone Klotho
2004-10-06 IGF-1 signaling and aging
2004-07-14 Sirtuin activators mimic caloric restriction and delay ageing in metazoans
2004-05-15 Klotho is a serum factor related to human aging
2004-03-31 On the road to immortality: hTERT upregulation in cancer cells
2002-09-15 Human Telomerase and Its Regulation
2002-04-29 Ageing and Longevity Are Related to Growth Hormone/Insulin-Like Growth Factor-1 Secretion
2002-01-15 Association of human aging with a functional variant of klotho
2001-02-01 Searching for Human Longevity Genes
2000-07-14 Transient expression of human telomerase extends the life span of normal human fibroblasts
2000-04-15 Expression of the hTERT Gene Is Regulated at the Level of Transcriptional Initiation and Repressed by Mad1
1999-10-01 The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae
1999-07-01 Kleemeier Award Lecture: Are There Genes for Aging?
1999-02-04 Telomerase reverse transcriptase gene is a direct target of c-Myc but…
1998-12-15 Telomerase activity in ‘immortal’ fish
1998-12-03 Longevity of lobsters is linked to ubiquitous telomerase expression
1998-01-16 Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
1997-11-06 Mutation of the mouse klotho gene leads to a syndrome resembling ageing
1994-12-23 Specific Association of Human Telomerase Activity With Immortal Cells and Cancer

04 Longevity Genes & Key Molecules

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